Lu AF21934

Lu AF21934 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 4 (mGluR4, EC50 = 500 nM for the human receptor in a FLIPR assay). It is selective for mGluR4 over mGluR6 (EC50 = 7 µM) and a panel of 73 CNS ion channels, G protein-coupled receptors (GPCRs), and enzymes at 10 µM. Lu AF21934 (12 mg/kg) reduces marble burying behavior and stress-induced hyperthermia in mice, indicating anxiolytic-like activity, but also reduces locomotor activity. It inhibits MK-801- and amphetamine-induced hyperactivity in mice and prevents MK-801-induced decreases in social interaction in rats. Lu AF21934 (0.5 and 2.5 mg/kg) also reduces harmaline-induced hyperactivity, but not tremor, in rats.Formal Name: N1-(3,4-dichlorophenyl)-1S,2R-cyclohexanedicarboxamide. CAS Number: 1445605-23-1. Molecular Formula: C14H16Cl2N2O2. Formula Weight: 315.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml. lambdamax: 211, 252 nm. SMILES: O=C(NC1=CC(Cl)=C(Cl)C=C1)[C@@H]2[C@H](C(N)=O)CCCC2. InChi Code: InChI=1S/C14H16Cl2N2O2/c15-11-6-5-8(7-12(11)16)18-14(20)10-4-2-1-3-9(10)13(17)19/h5-7,9-10H,1-4H2,(H2,17,19)(H,18,20)/t9-,10+/m1/s1. InChi Key: AVKZWCJNDWOBAM-ZJUUUORDSA-N.