LP44 (hydrochloride)

LP44 is a full agonist of the serotonin 5-HT7 receptor (Ki = 0.22 nM) that displays 200- and greater than 1,000-fold selectivity over 5-HT1A (Ki = 52.7 nM) and 5-HT2A (Ki = 326 nM) receptors, respectively. It can induce relaxation of substance P-induced guinea pig ileum contraction with an EC50 value of 2.56 µM.Formal Name: 4-[2-(methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide, monohydrochloride. CAS Number: 824958-12-5. Molecular Formula: C27H37N3OS . HCl. Formula Weight: 488.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml, Ethanol: 10 mg/ml. SMILES: O=C(CCCCCN1CCN(C2=C(SC)C=CC=C2)CC1)NC3CCCC4=CC=CC=C43.Cl. InChi Code: InChI=1S/C27H37N3OS.ClH/c1-32-26-15-7-6-14-25(26)30-20-18-29(19-21-30)17-8-2-3-16-27(31)28-24-13-9-11-22-10-4-5-12-23(22)24,/h4-7,10,12,14-15,24H,2-3,8-9,11,13,16-21H2,1H3,(H,28,31),1H. InChi Key: DWGKCWWWKHCVDH-UHFFFAOYSA-N.