Losartan Carboxylic Acid

Description: Losartan Carboxylic Acid (E-3174), a potent AT1 antagonist (Kis: 0.57 nM, rat, 0.67 nM, human), produces a depressor response and vasodilatation. As a metabolite of losartan, it is more potent than losartan in blocking angiotensin II-induced responses in vascular smooth muscle cells. Target: RAAS. Smiles: C(N1C(CCCC)=NC(Cl)=C1C(O)=O)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4. References: Choi JS, Choi JS, Choi DH. Effects of licochalcon A on the pharmacokinetics of losartan and its active metabolite, EXP-3174, in rats. Pharmazie. 2013 Nov,68(11):882-8.