Lonidamine

Lonidamine, originally identified as a potent antispermatogenic agent, inhibits glycolysis though the inactivation of mitochondria-bound hexokinase. It can decrease oxygen consumption as well as aerobic and anaerobic glycolysis in Ehrlich ascites tumor cells with IC50 values of 90 and 45 µM, respectively. A role for lonidamine as a therapeutic for mitochondrial dysfunction has been explored in various disorders, including cancer, neurodegenerative and neuromuscular diseases, obesity, and diabetes.Formal Name: 1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid. CAS Number: 50264-69-2. Synonyms: AF 1890, DICA, Diclondazolic Acid. Molecular Formula: C15H10Cl2N2O2. Formula Weight: 321.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1.7 mg/ml. lambdamax: 298 nm. SMILES: OC(C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C31)=O. InChi Code: InChI=1S/C15H10Cl2N2O2/c16-10-6-5-9(12(17)7-10)8-19-13-4-2-1-3-11(13)14(18-19)15(20)21/h1-7H,8H2,(H,20,21). InChi Key: WDRYRZXSPDWGEB-UHFFFAOYSA-N.