LMB763

LMB763 is a partial agonist of the farnesoid X receptor (FXR, EC50 = 7 nM). It is selective for FXR over a panel of enzymes, ion channels, nuclear receptors, and G protein-coupled receptors, including the androgen receptor, estrogen receptor alpha (ERalpha), and G protein-coupled bile acid receptor 1 (GPBAR1, EC50s = >30, >30, and >80 µM, respectively). LMB763 induces expression of the FXR target genes encoding the bile salt export pump and short heterodimer partner in isolated rat hepatocytes in a concentration-dependent manner. It decreases non-alcoholic fatty liver disease (NAFLD) scores and liver fibrosis in a rat model of non-alcoholic steatohepatitis (NASH).Formal Name: 4-[[[(8-chloro-1,4-dihydro-1-methyl[1]benzopyrano[4,3-c]pyrazol-3-yl)carbonyl](phenylmethyl)amino]methyl]-benzoic acid. CAS Number: 1773489-72-7. Synonyms: Nidufexor. Molecular Formula: C27H22ClN3O4. Formula Weight: 487.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 232 nm. SMILES: ClC1=CC=C(OCC2=C3N(C)N=C2C(N(CC4=CC=CC=C4)CC5=CC=C(C(O)=O)C=C5)=O)C3=C1. InChi Code: InChI=1S/C27H22ClN3O4/c1-30-25-21-13-20(28)11-12-23(21)35-16-22(25)24(29-30)26(32)31(14-17-5-3-2-4-6-17)15-18-7-9-19(10-8-18)27(33)34/h2-13H,14-16H2,1H3,(H,33,34). InChi Key: JYTIXGYXBIBOMN-UHFFFAOYSA-N.