Lixivaptan

Lixivaptan is a nonpeptide antagonist of vasopressin V2 receptors (Ki = 2.3 nM). It is 100-fold selective for V2 over V1a. Formulations containing lixivaptan decrease urinary excretion of aquaporin-2 in patients with chronic heart failure and increase serum sodium levels in patients with hyponatremia due to congestive heart failure.Formal Name: N-[3-chloro-4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)phenyl]-5-fluoro-2-methyl-benzamide. CAS Number: 168079-32-1. Synonyms: VPA-985, WAY-VPA-985. Molecular Formula: C27H21ClFN3O2. Formula Weight: 473.9. Purity: >97%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml, Ethanol: 10 mg/ml. lambdamax: 268 nm. SMILES: CC1=CC=C(F)C=C1C(NC2=CC(Cl)=C(C(N3C(C=CC=C4)=C4CN5C(C3)=CC=C5)=O)C=C2)=O. InChi Code: InChI=1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33). InChi Key: PPHTXRNHTVLQED-UHFFFAOYSA-N.