Linagliptin

White to off-white solid. Soluble in DMSO, ethanol or methanol. Slightly soluble in water (~1mg/ml). Antidiabetic agent, Highly potent and selective competitive inhibitor of dipeptidyl-peptidase 4 (DPP4, DPP IV, CD26), an enzyme that degrades, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Prevents the inactivation of endogenous GLP-1 and GIP, Shown to restore beta cell function and survival in human isolated islets through GLP-1 stabilization, Improves insulin sensitivity, Anti-inflammatory compound.