Linaclotide acetate

Description: Linaclotide acetate is used as an oral guanylate cyclase C agonist linaclotide, 14 amino acid peptide for the potential treatment of constipation-predominant irritable bowel syndrome and chronic idiopathic constipation. Target: Others. Smiles: C(C)(O)=O.O=C1N2[C@@](CCC2)(C(=O)N[C@@H](C)C(=O)N[C@@]3(C(=O)N[C@@]([C@@H](C)O)(C(=O)NCC(=O)N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(O)=O)=O)CSSC[C@]5(C(=O)N[C@](C(=O)N[C@H]1CC(N)=O)(CSSC[C@H](N)C(=O)N[C@@](CSSC3)(C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC6=CC=C(O)C=C6)C(=O)N5)[H])[H])[H])[H])[H])[H]. References: Layer P, Stanghellini V. Review article: Linaclotide for the management of irritable bowel syndrome with constipation. Aliment Pharmacol Ther. 2014 Feb,39(4):371-84. doi: 10.1111/apt.12604. Epub 2014 Jan 16. Review. PubMed PMID: 24433216, PubMed Central PMCID: PMC4305214.