Limaprost

Description: Limaprost (17alpha,20-dimethyl-delta2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost (17alpha,20-dimethyl-delta2-PGE1) can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment. Target: PGE Synthase. Smiles: CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(O)=O. References: Tsuboi T, et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn Ther. 1980 Sep,247(1):89-102.