LG 100268

LG 100268 is an agonist of retinoid X receptors (RXRs, Kd = 3 nM). It is selective for RXRs over retinoic acid receptors (RARs, Kd = >10,000 nM). In vitro, LG 100268 (1 µM) induces apoptosis in HL-60 human leukemia cells when used in combination with TTNPB (Cay-16144). LG 100268 (100, 300, and 1,000 nM) dose-dependently inhibits COX-2 expression and increases ATP-binding cassette transporter (ABCA1) levels in macrophage-like RAW 264.7 cells. In vivo, it inhibits vinyl carbamate-induced lung tumor growth in mice when administered at a dose of 40 mg/kg.Formal Name: 6-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)cyclopropyl]-3-pyridinecarboxylic acid. CAS Number: 153559-76-3. Synonyms: AGN 192620, CD3127. Molecular Formula: C24H29NO2. Formula Weight: 363.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20mg/mL, DMSO: 20mg/mL, Ethanol: 1mg/mL. lambdamax: 271, 318 nm. SMILES: CC1(C)C2=C(C=C(C)C(C3(CC3)C4=NC=C(C(O)=O)C=C4)=C2)C(C)(C)CC1. InChi Code: InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27). InChi Key: SLXTWXQUEZSSTJ-UHFFFAOYSA-N.