Levosimendan

Description: Levosimendan (OR1259) is a calcium sensitizer used in the management of acutely decompensated congestive heart failure. It increases the sensitivity of the heart to calcium, thus increasing cardiac contractility without a rise in intracellular calcium. Levosimendan exerts its effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner. Target: PDE, Carbonic Anhydrase, Potassium Channel, Autophagy. Smiles: C[C@H]1C(C2=CC=C(NN=C(C#N)C#N)C=C2)=NNC(=O)C1. References: Haikala H, J Mol Cell Cardiol, 1995, 27(9), 1859-1866.