Levorin Complex

Levorin complex is a macrocyclic heptaene antifungal complex originally isolated from S. griseus. It is active against C. albicans, T. glabrata, A. niger, T. mentagrophytes, and T. soudanense in vitro (MICs = 0.03-25 µg/ml). Oral administration of levorin complex reduces mortality in a mouse model of C. albicans infection with a protective dose (PD50) value of 25 mg/kg. This product is a mixture of levorin A0, levorin A2, and levorin A3.CAS Number: 1403-17-4. Molecular Formula: C59H86N2O18 (for Levorin A3). Formulation: (Request formulation change), A solid. Solubility: DMSO: Slightly soluble, heated. lambdamax: 360, 380, 403 nm. SMILES: O[C@@H]1[C@]([H])(O[C@H](C[C@H](O)[C@H](C(O)=O)[C@@H](O)CC(C[C@@H](O)C[C@@H](O)C[C@@H](O)CC(CCCC(C2)=O)=O)=O)/C=C/C=C\C=C/C=C\C=C\C=C\C=C\[C@H](C)[C@]([C@@H](C)C[C@H](C)[C@@H](O)CC(C3=CC=C(N)C=C3)=O)([H])OC2=O)O[C@@H]([C@H]([C@@H]1N)O)C. InChi Code: InChI=1S/C59H84N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-47(78-59-56(74)54(61)55(73)38(4)77-59)33-51(71)53(58(75)76)50(70)31-46(67)30-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)32-52(72)79-57(35)37(3)26-36(2)48(68)34-49(69)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,43-45,47-48,50-51,53-57,59,64-66,68,70-71,73-74H,17,19-20,26-34,60-61H2,1-4H3,(H,75,76)/b6-5-,9-7+,10-8-,13-11+,14-12-,18-15+,21-16+/t35-,36-,37-,38+,43-,44-,45-,47-,48-,50-,51-,53+,54-,55+,56-,57-,59-/m0/s1. InChi Key: OPGSFDUODIJJGF-YLAUPCTOSA-N. Origin: Bacterium/Streptomyces griseus.