Levonordefrin

Levonordefrin is the (-)-enantiomer of nordefrin, a synthetic derivative of norepinephrine (Cay-16673), that acts as a vasoconstrictor. Levonordefrin (1-5 µg/kg) rapidly increases blood pressure and heart rate in anesthetized dogs and has a more potent effect on blood pressure than the dextronordefrin enantiomer. It also inhibits carbamylcholine-induced uterine contractions in isolated rat uterine strips (EC50 = 0.0032 µg/ml). Levonordefrin (0.514 and 1.542 mg/kg), in combination with mepivacaine (Cay-23402) and administered via intraoral infiltration, increases systolic arterial blood pressure in anesthetized dogs, however, the effect is not dose-dependent and the increase is not greater than 5.33%. Formulations containing levonordefrin have been used in combination with local anesthetics in dentistry to prolong anesthetic effects.Formal Name: 4-[(1R,2S)-2-amino-1-hydroxypropyl]-1,2-benzenediol. CAS Number: 829-74-3. Synonyms: Corbadrine, (-)-alpha-methyl Noradrenaline, (-)-3,4-dihydroxy Norephedrine. Molecular Formula: C9H13NO3. Formula Weight: 183.2. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 5 mg/ml. SMILES: OC1=C(O)C=CC([C@@H](O)[C@@H](N)C)=C1. InChi Code: InChI=1S/C9H13NO3/c1-5(10)9(13)6-2-3-7(11)8(12)4-6/h2-5,9,11-13H,10H2,1H3/t5-,9-/m0/s1. InChi Key: GEFQWZLICWMTKF-CDUCUWFYSA-N.