Levolansoprazole

Description: Levolansoprazole ((S)-Lansoprazole), a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 µM). It also inhibits acid formation in isolated canine parietal cells (IC50: 82 µM). Both (R)- and (S)-lansoprazole are pharmacologically active with similar potencies. Target: Proton pump. Smiles: S(CC1=C(C)C(OCC(F)(F)F)=CC=N1)(=O)C=2NC=3C(N2)=CC=CC3. References: Gellad WF, Choi P, Mizah M, Good CB, Kesselheim AS. Assessing the chiral switch: approval and use of single-enantiomer drugs, 2001 to 2011. Am J Manag Care. 2014 Mar 1,20(3):e90-7. PubMed PMID: 24773330.