Letermovir

Letermovir is a small molecule inhibitor of human cytomegalovirus viral replication (EC50 = ~5 nM with a selectivity index >15,000) that targets viral DNA cleavage and packaging. It functions to prevent viral DNA concatemers from forming the proper unit length and interferes with virion maturation.Formal Name: (4S)-8-fluoro-3,4-dihydro-2-[4-(3-methoxyphenyl)-1-piperazinyl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4-quinazolineacetic acid. CAS Number: 917389-32-3. Synonyms: AIC246. Molecular Formula: C29H28F4N4O4. Formula Weight: 572.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 214, 256 nm. SMILES: OC(C[C@H]1C2=CC=CC(F)=C2N=C(N3CCN(C4=CC(OC)=CC=C4)CC3)N1C5=C(OC)C=CC(C(F)(F)F)=C5)=O. InChi Code: InChI=1S/C29H28F4N4O4/c1-40-20-6-3-5-19(16-20)35-11-13-36(14-12-35)28-34-27-21(7-4-8-22(27)30)23(17-26(38)39)37(28)24-15-18(29(31,32)33)9-10-25(24)41-2/h3-10,15-16,23H,11-14,17H2,1-2H3,(H,38,39)/t23-/m0/s1. InChi Key: FWYSMLBETOMXAG-QHCPKHFHSA-N.