Leflunomide-d4

Leflunomide-d4 is intended for use as an internal standard for the quantification of leflunomide (Cay-14860) by GC- or LC-MS. Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 (Cay-14404), a dihydroorotate dehydrogenase inhibitor. Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of 25 and 100 µM, respectively, for naïve and memory CD4+ T cells. It also reduces the production of Th1 effector cells and increases differentiation of Th2 cells in vitro and in splenocytes isolated from KLH-immunized mice. Leflunomide (35 mg/kg per day) reduces and prevents inflammation in a proteoglycan-induced mouse model of rheumatoid arthritis. Formulations containing leflunomide have been used in the treatment of active rheumatoid arthritis.Formal Name: 5-methyl-N-(4-(trifluoromethyl)phenyl-2,3,5,6-d4)isoxazole-4-carboxamide. CAS Number: 1189987-23-2. Molecular Formula: C12H5D4F3N2O2. Formula Weight: 274.2. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Methanol: soluble. SMILES: O=C(C1=C(C)ON=C1)NC2=C([2H])C([2H])=C(C(F)(F)F)C([2H])=C2[2H]. InChi Code: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)/i2D,3D,4D,5D. InChi Key: VHOGYURTWQBHIL-QFFDRWTDSA-N.