LCS3

Description: LCS3 is a reversible and non-competitive synergistic inhibitor of glutathione disulfide reductase (GSR) and thioredoxin reductase 1 (TXNRD1) with IC50s of 3.3 µM and 3.8 µM, respectively. LCS3 has antitumour activity, induces apoptosis and can be used in the study of lung adenocarcinoma (LUAD). Target: Apoptosis, Glutathione reductase. Smiles: [O-][N+](=O)C1=CC=C(O1)C(=O)NC1=CC=C(Cl)C=C1. References: Johnson FD, et al. Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells. Cell Rep. 2022 , 38(6):110343.