LCQ-908

LCQ-908 is an inhibitor of diacylglycerol acyltransferase 1 (DGAT1, IC50 = 57 nM). It is selective for DGAT1 over DGAT2, acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1), and ACAT-2 (IC50s = >10,000 nM for all). LCQ-908 (50 µM) also inhibits hepatitis C virus (HCV) replication in HCV-infected Huh7.5 cells. It inhibits palmitic acid-induced apoptosis and increases in triglyceride levels in MIN6 pancreatic beta-cells when used at a concentration of 1 µM. In vivo, LCQ-908 (1 mg/kg) decreases serum triglyceride levels in an oral lipid tolerance test in dogs.Formal Name: trans-4-[4-[5-[[6-(trifluoromethyl)-3-pyridinyl]amino]-2-pyridinyl]phenyl]-cyclohexaneacetic acid. CAS Number: 956136-95-1. Synonyms: Pradigastat. Molecular Formula: C25H24F3N3O2. Formula Weight: 455.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml. SMILES: OC(C[C@@H](CC1)CC[C@H]1C(C=C2)=CC=C2C3=CC=C(C=N3)NC4=CN=C(C=C4)C(F)(F)F)=O. InChi Code: InChI=1S/C25H24F3N3O2/c26-25(27,28)23-12-10-21(15-30-23)31-20-9-11-22(29-14-20)19-7-5-18(6-8-19)17-3-1-16(2-4-17)13-24(32)33/h5-12,14-17,31H,1-4,13H2,(H,32,33)/t16-,17-. InChi Key: GXALXAKNHIROPE-QAQDUYKDSA-N.