LCK Inhibitor

Lymphocyte-specific protein tyrosine kinase (LCK) is a member of the Src-family of non-receptor protein tyrosine kinases and plays a critical role in the initial steps of T cell receptor signaling that trigger the production of cytokines. LCK inhibitor is a pyrrolopyrimidine that blocks the activity of two forms of LCK kinase, LCK (64-509) and LCKCD, with IC50 values of 50s = 70 nM, 1.57, and 1.98 µM, respectively) and only minimally inhibits the activities of EGFR, PKC, CDC2/B and ZAP-70 (IC50s = 3.2, >33, >50, and >50 µM, respectively). This compound has been shown to inhibit T cell receptor-stimulated IL-2 production in mice (ED50s = 4 and 25 mg/kg when administered either i.p. or orally).Formal Name: 7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine. CAS Number: 213743-31-8. Synonyms: Lymphocyte-specific Protein Tyrosine Kinase, RK-24466. Molecular Formula: C23H22N4O. Formula Weight: 370.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 12 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml, DMSO: 2.5 mg/ml, Ethanol: 0.33 mg/ml. lambdamax: 258, 283 nm. SMILES: NC1=C2C(C(C=C3)=CC=C3OC4=CC=CC=C4)=CN(C5CCCC5)C2=NC=N1. InChi Code: InChI=1S/C23H22N4O/c24-22-21-20(14-27(17-6-4-5-7-17)23(21)26-15-25-22)16-10-12-19(13-11-16)28-18-8-2-1-3-9-18/h1-3,8-15,17H,4-7H2,(H2,24,25,26). InChi Key: FMETVQKSDIOGPX-UHFFFAOYSA-N.