LATS-IN-1

LATS-IN-1 is an inhibitor of large tumor suppressor kinase 1 (LATS1) and LATS2 (IC50 = 2 nM for both), key regulators of Hippo regenerative signaling. It inhibits phosphorylation of YES1-associated transcriptional regulator (YAP1) in serum-starved HEK293A cells (EC50 = 510 nM). LATS-IN-1 (10 µM) increases the proliferation of Müller glial cells and isolated mouse cardiomyocytes.Formal Name: N-[3-(phenylmethyl)-2(3H)-thiazolylidene]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide. CAS Number: 1424635-83-5. Synonyms: LATS Inhibitor 1, TRULI. Molecular Formula: C18H14N4OS. Formula Weight: 334.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml. lambdamax: 330 nm. SMILES: O=C(C1=CNC2=C1C=CC=N2)N=C3SC=CN3CC4=CC=CC=C4. InChi Code: InChI=1S/C18H14N4OS/c23-17(15-11-20-16-14(15)7-4-8-19-16)21-18-22(9-10-24-18)12-13-5-2-1-3-6-13/h1-11H,12H2,(H,19,20). InChi Key: VTXBMVZVPUSAJF-UHFFFAOYSA-N.