L002

Description: L002, a potent, cell-permeable, reversible, and specific acetyltransferase p300 (KAT3B) inhibitor with an IC50 of 1.98 µM, directly binds the acetyl-CoA pocket and competitively inhibits the FATp300 catalytic domain. By blocking histone acetylation, p53 acetylation, and STAT3 activation, L002 shows potential in the treatment of hypertension-induced cardiac hypertrophy and fibrogenesis. Target: Others, STAT, Histone Acetyltransferase. Smiles: COc1ccc(cc1)S(=O)(=O)ON=C1C=C(C)C(=O)C(C)=C1. References: Rai R, et al. A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis. Epigenetics. 2017,12(11):1004-1013.