L-Selenocystine

L-Selenocystine is a diselenide-bridged amino acid that may be confused with selenocysteine (Sec), which is a rare amino acid featuring a single selenium atom. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions. This compound can be reduced by low molecular thiols and disulfide reductases to Sec. It is reduced to Sec by mammalian thioredoxin reductase (apparent Km = 6.0 µM), and this property can be used to assay thioredoxin reductase activity. L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types.Formal Name: 3,3'-diselenobis-L-alanine. CAS Number: 29621-88-3. Synonyms: Seleno-L-cystine. Molecular Formula: C6H12N2O4Se2. Formula Weight: 334.1. Purity: >90%. Formulation: (Request formulation change), A crystalline solid. SMILES: OC([C@@H](N)C[Se][Se]C[C@H](N)C(O)=O)=O. InChi Code: InChI=1S/C6H12N2O4Se2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m0/s1. InChi Key: JULROCUWKLNBSN-IMJSIDKUSA-N.