L-NNA

L-NNA is a competitive inhibitor of nitric oxide synthase (NOS) with selectivity for the neuronal and endothelial isoforms of the enzyme. Although L-NAME is much more soluble than L-NNA in aqueous systems, a hydrolysis step is required to "activate" L-NAME, thus adding complexity to an in vivo experiment. L-NNA inhibits nNOS, eNOS, and iNOS with Ki values of 15 nM (bovine), 39 nM (human), and 4.4 µM (mouse), respectively.Formal Name: N5-[imino(nitroamino)methyl]-L-ornithine. CAS Number: 2149-70-4. Synonyms: L-NG-Nitroarginine, NG-nitro-L-Arginine. Molecular Formula: C6H13N5O4. Formula Weight: 219.2. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: <50 µg/ml, DMSO: <50 µg/ml, Ethanol: <50 µg/ml, PBS pH 7.2: 1 mg/ml. SMILES: N=C(NCCC[C@H](N)C(=O)O)N[N](=O)O. InChi Code: InChI=1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10). InChi Key: MRAUNPAHJZDYCK-UHFFFAOYSA-N. Origin: Synthetic.