L-Kynurenine-d4

L-Kynurenine-d4 is intended for use as an internal standard for the quantification of kynurenine by GC- or LC-MS. L-Kynurenine is an active metabolite of tryptophan (Cay-29600, Cay-31210). It is formed from tryptophan via tryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR, Kd = ~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50 = 12.3 µM). It decreases intracellular concentrations of NAD+ (Cay-16077) in, and increases lactate dehydrogenase (LDH) activity in the supernatant of, primary human astrocytes and neurons in a concentration-dependent manner. L-Kynurenine in combination with IFN-gamma reduces lung injury induced by A. fumigatus infection in the p47phox-/- mouse model of chronic granulomatous disease.Formal Name: (S)-2-amino-4-(2-aminophenyl-3,5-d2)-4-oxobutanoic-3,3-d2 acid. CAS Number: 2672568-86-2. Synonyms: 3-anthraniloyl-Alanine-d4, L-KYN-d4. Molecular Formula: C10H8D4N2O3. Formula Weight: 212.2. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: 0.5 mg/ml, DMSO: 1 mg/ml, Ethanol: 2 mg/ml. SMILES: [2H]C1=CC([2H])=C(N)C(C(C([2H])([C@@H](C(O)=O)N)[2H])=O)=C1. InChi Code: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1/i1D,4D,5D2. InChi Key: YGPSJZOEDVAXAB-LVQMRTGASA-N.