L-Homoarginine (hydrochloride)

L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [3H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.Formal Name: N6-(aminoiminomethyl)-L-lysine, monohydrochloride. CAS Number: 1483-01-8. Synonyms: NSC 145416. Molecular Formula: C7H16N4O2 . HCl. Formula Weight: 224.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: NC(NCCCC[C@H](N)C(O)=O)=N.Cl. InChi Code: InChI=1S/C7H16N4O2.ClH/c8-5(6(12)13)3-1-2-4-11-7(9)10,/h5H,1-4,8H2,(H,12,13)(H4,9,10,11),1H/t5-,/m0./s1. InChi Key: YMKBVNVCKUYUDM-JEDNCBNOSA-N.