L-Biopterin

L-Biopterin is the oxidized form of tetrahydro-L-biopterin (BH4), a nitric oxide synthase (NOS) cofactor. L-Biopterin can be reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. It is extremely toxic to human melanocytes in culture (IC50 = 0.2 µM after 48 hrs). L-Biopterin is rarely found under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo.Formal Name: 2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone. CAS Number: 22150-76-1. Synonyms: L-erythro-Biopterin, NSC 339699. Molecular Formula: C9H11N5O3. Formula Weight: 237.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.3 mg/ml, DMSO: 1 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 276, 348 nm. SMILES: NC(N=C1C2=NC([C@@H](O)[C@@H](O)C)=CN1[H])=NC2=O. InChi Code: InChI=1S/C9H11N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h2-3,6,15-16H,1H3,(H3,10,11,13,14,17)/t3-,6-/m0/s1. InChi Key: LHQIJBMDNUYRAM-DZSWIPIPSA-N.