L-779,450

L-779,450 is an ATP-competitive B-Raf inhibitor (IC50 = 10 nM, Kd = 2.4 nM) that displays >7, >30, and >70-fold selectivity over p38alpha, GSK3beta, and Lck, respectively. It has been shown to inhibit cell proliferation both in B-Raf mutated and wild-type melanoma cell lines, as well as to enhance tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in these cells.Formal Name: 2-chloro-5-[2-phenyl-4-(4-pyridinyl)-1H-imidazol-5-yl]-phenol. CAS Number: 303727-31-3. Synonyms: Raf Kinase Inhibitor IV. Molecular Formula: C20H14ClN3O. Formula Weight: 347.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMF:PBS (pH 7.2), (1:7): 0.12 mg/mL, DMSO: 30 mg/mL, Ethanol: 2 mg/mL. lambdamax: 251, 295 nm. SMILES: OC1=CC(C(N2)=C(C3=CC=NC=C3)N=C2C4=CC=CC=C4)=CC=C1Cl. InChi Code: InChI=1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24). InChi Key: WXJLXRNWMLWVFB-UHFFFAOYSA-N.