L-694,247

L-694,247 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1D. It is selective for 5-HT1D over the 5-HT1A, 5-HT1C, 5-HT1E, 5-HT2, and 5-HT3 receptors (Kis = 0.093, 2.29, 380, 2,187, 316, and >10,000 nM, respectively). L-694,247 inhibits adenylyl cyclase activity induced by forskolin (Cay-11018) in guinea pig substantia nigra homogenates and potassium-induced 5-HT release in isolated guinea pig frontal cortex strips (EC50s = 0.79 and 0.4 nM, respectively). It decreases water intake in dehydrated rats as well as prevents carbachol-, angiotensin II-, or isoproterenol-induced increases in water intake in normohydrated rats in a dose-dependent manner. Intra-atrial administration of L-694,247 (0.00000125-0.1 µg/kg) decreases renal perfusion pressure but does not affect systolic blood pressure or heart rate in in situ autoperfused rat kidney infused with phenylephrine (Cay-17205, Cay-18619).Formal Name: N-[4-[[5-[3-(2-aminoethyl)-1H-indol-5-yl]-1,2,4-oxadiazol-3-yl]methyl]phenyl]-methanesulfonamide. CAS Number: 137403-12-4. Molecular Formula: C20H21N5O3S. Formula Weight: 411.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 100 mM. SMILES: O=S(NC1=CC=C(CC2=NOC(C3=CC=C4NC=C(CCN)C4=C3)=N2)C=C1)(C)=O. InChi Code: InChI=1S/C20H21N5O3S/c1-29(26,27)25-16-5-2-13(3-6-16)10-19-23-20(28-24-19)14-4-7-18-17(11-14)15(8-9-21)12-22-18/h2-7,11-12,22,25H,8-10,21H2,1H3. InChi Key: HKXMQLISPYELRD-UHFFFAOYSA-N.