KX1-004

KX1-004 is a non-ATP competitive inhibitor of Src protein tyrosine kinase (Src-PTK, IC50 = 40 µM). It protects against a permanent threshold shift in the auditory threshold and against outer hair cell loss in chinchillas following noise exposure at 106 dB when used at 30, 50, or 100 µM on the round window membrane of the ear. KX1-004 (50 mg/kg) is also effective against chronic noise exposure when administered systemically in chinchillas.Formal Name: 5-fluoro-N-[(3-hydroxyphenyl)methyl]-1H-indole-2-carboxamide. CAS Number: 518058-84-9. Molecular Formula: C16H13FN2O2. Formula Weight: 284.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 20 mg/ml, Ethanol: 2.5 mg/ml. lambdamax: 289 nm. SMILES: FC1=CC=C2C(C=C(C(NCC3=CC=CC(O)=C3)=O)N2)=C1. InChi Code: InChI=1S/C16H13FN2O2/c17-12-4-5-14-11(7-12)8-15(19-14)16(21)18-9-10-2-1-3-13(20)6-10/h1-8,19-20H,9H2,(H,18,21). InChi Key: TUIHIKXCMCXXJG-UHFFFAOYSA-N.