KT 5823

The activity of cGMP-dependent protein kinase (PKG) is controlled by factors that elevate cellular cGMP, like nitric oxide (NO), and by those that reduce cGMP levels, like certain phosphodiesterases. KT 5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50 = 234 nM). KT 5823 is cell-permeable and is often used in intact cells to assess the role of PKG in signaling, although there are cases where it poorly inhibits PKG in cells. KT 5823 is a weak inhibitor of PKC (Ki = 4 µM) and PKA (Ki >10 µM).Formal Name: 2,3,9,10,11,12-hexahydro-10R-methoxy-2,9-dimethyl-1-oxo-9S,12R-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester. CAS Number: 126643-37-6. Molecular Formula: C29H25N3O5. Formula Weight: 495.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 20 mg/ml, Ethyl Acetate: 1 mg/ml. lambdamax: 292 nm. SMILES: C[C@]1([C@@]2(OC)C(OC)=O)N(C3=CC=CC=C43)C5=C4C(CN6C)=C(C6=O)C(C7=CC=CC=C87)=C5N8[C@@H](C2)O1. InChi Code: InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1. InChi Key: QTYMDECKVKSGSM-YMUMJAELSA-N.