KS-176

KS-176 is a selective inhibitor of breast cancer resistance protein (BRCP, IC50 = 1.39 µM) with no activity against P-glycoprotein (P-gp) or multidrug resistance-associated protein 1 (MRP1). It acts as a non-competitive inhibitor whose potency is increased by imatinib binding. KS-176 does not reduce cell viability at concentrations up to 10 µM.Formal Name: N-[4-(2-hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]-benzamide. CAS Number: 1253452-78-6. Molecular Formula: C22H19N3O5. Formula Weight: 405.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml. lambdamax: 260 nm. SMILES: O=C(NC1=C(C(NC2=CC=C(CCO)C=C2)=O)C=CC=C1)C3=CC=C([N+]([O-])=O)C=C3. InChi Code: InChI=1S/C22H19N3O5/c26-14-13-15-5-9-17(10-6-15)23-22(28)19-3-1-2-4-20(19)24-21(27)16-7-11-18(12-8-16)25(29)30/h1-12,26H,13-14H2,(H,23,28)(H,24,27). InChi Key: LTWQQWSXYYXVGA-UHFFFAOYSA-N.