KP372-1

KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3beta, LCK, MEK1, PKA, PKC, and S6K. In acute myelogenous leukemia cells, KP372-1 is reported to inhibit the kinase activity of Akt, PDK1, and FLT3, decreasing the colony-forming ability of these cells with an IC50 value less than 200 nM.Formal Name: 6H-indeno[1,2-epsilon]tetrazolo[1,5-b][1,2,4]triazin-6-one, compd. with 10H-indeno[2,1-epsilon]tetrazolo[1,5-b][1,2,4]triazin-10-one (1:1). CAS Number: 1374996-60-7. Molecular Formula: C10H4N6O . C10H4N6O. Formula Weight: 224.2. Purity: >95% (sum of isomers). Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml. lambdamax: 218, 267 nm. SMILES: O=C(C1=C2C=CC=C1)C(C2=N3)=NN4C3=NN=N4.O=C5C6=NC7=NN=NN7N=C6C8=C5C=CC=C8. InChi Code: InChI=1S/2C10H4N6O/c17-9-6-4-2-1-3-5(6)7-8(9)11-10-12-14-15-16(10)13-7,17-9-6-4-2-1-3-5(6)7-8(9)13-16-10(11-7)12-14-15-16/h2*1-4H. InChi Key: CWFOAASSUQIXOW-UHFFFAOYSA-N.