KN-93

Description: KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase. Target: CaMK, Autophagy. Smiles: N(S(=O)(=O)C1=CC=C(OC)C=C1)(CCO)C2=C(CN(CC=CC3=CC=C(Cl)C=C3)C)C=CC=C2. References: Tombes RM, et al. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK (the multifunctional Ca2+/CaM kinase). Cell Growth Differ. 1995 Sep,6(9):1063-70.