KMH-233

Description: KMH-233 is a potent selective LAT1 inhibitor 1 that inhibits the uptake of LAT1 substrate, L-leucine, and cell growth. Even at low concentrations (25 µM), it significantly enhanced the efficacy of betastatin and cisplatin. Target: Others. Smiles: CNC(=O)COc1ccc(cc1)-c1c(C#N)c(NC(=O)c2cccc(C[C@H](N)C(O)=O)c2)n2c3ccccc3nc2c1C#N. References: A Selective and Slowly Reversible Inhibitor of l-Type Amino Acid Transporter 1 (LAT1) Potentiates Antiproliferative Drug Efficacy in Cancer Cells Kristiina M. Huttunen, Mikko Gynther, Johanna Huttunen, Elena Puris, Julie A. Spicer, and William A. Denny Publication Date (Web): June 2, 2016 (Article) doi: 10.1021/acs.jmedchem.6b00190