KIRA6

KIRA6
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay19151-1 1 mg -

6 - 10 Werktage*

50,00 €
Cay19151-5 5 mg -

6 - 10 Werktage*

191,00 €
Cay19151-10 10 mg -

6 - 10 Werktage*

286,00 €
 
The IRE1 pathway is a component of the unfolded protein response that senses unfolded proteins... mehr
Produktinformationen "KIRA6"
The IRE1 pathway is a component of the unfolded protein response that senses unfolded proteins via an ER luminal domain that becomes oligomerized during stress. It is associated with promoting cell survival through the activity of the IRE1alpha RNase, whose activity upregulates proteins that enhance ER protein folding and quality control. However, under high ER stress, the IRE1alpha RNase becomes hyperactive and is less discriminant in its substrate specificity, endonucleolytically cleaving many additional mRNAs that localize to the ER membrane, leading to cell proliferation blocks, inflammation, and apoptosis. KIRA6 is an ATP-competitive IRE1alpha kinase inhibiting RNase attenuator (KIRA) that allosterically inhibits IRE1alpha RNase kinase activity (IC50 = 0.6 µM) and prevents oligomerization. It has been shown to inhibit IRE1alpha in vivo and to promote cell survival under ER stress. At 20 µg/ml, KIRA6 is reported to preserve photoreceptor functional viability in rat models of ER stress-induced retinal degeneration. At 5 mg/kg, it has also been shown to preserve pancreatic beta cells, increase insulin, and reduce hyperglycemia in Akita diabetic mice.Formal Name: N-[4-[8-amino-3-(1,1-dimethylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]-urea. CAS Number: 1589527-65-0. Synonyms: IRE1 Inhibitor IV, IRE1alpha Kinase Inhibiting RNase Attenuator 6. Molecular Formula: C28H25F3N6O. Formula Weight: 518.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS(pH7.2) (1:2): 0.3 mg/ml, DMSO: 20 mg/ml, Ethanol: 5 mg/ml. lambdamax: 228, 292, 330 nm. SMILES: NC1=NC=CN2C1=C(C3=C(C=CC=C4)C4=C(NC(NC5=CC(C(F)(F)F)=CC=C5)=O)C=C3)N=C2C(C)(C)C. InChi Code: InChI=1S/C28H25F3N6O/c1-27(2,3)25-36-22(23-24(32)33-13-14-37(23)25)20-11-12-21(19-10-5-4-9-18(19)20)35-26(38)34-17-8-6-7-16(15-17)28(29,30)31/h4-15H,1-3H3,(H2,32,33)(H2,34,35,38). InChi Key: NOHQEAFAESMMDX-UHFFFAOYSA-N.
Schlagworte: IRE1 Inhibitor IV, IRE1alpha Kinase Inhibiting RNase Attenuator 6, N-[4-[8-amino-3-(1,1-dimethylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]-urea
Hersteller: Cayman Chemical
Hersteller-Nr: 19151

Eigenschaften

Anwendung: ATP-competitive IRE1alpha kinase inhibiting RNase attenuator
MW: 518.5 D
Formel: C28H25F3N6O
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 1589527-65-0| Passende Produkte
KEGG ID : K08852 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H315, H319, H335
P-Sätze: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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