KIN1148

Description: KIN1148 is a novel small-molecule adjuvant that acts through the RIG-I pathway and IRF-3 transcription factor to stimulate inN/Ate immunity and protection following viral infection. The adjuvant will be developed for an FDA-approved avian inluenza virus vaccine as well as evaluation in flavivirus vaccine platforms, including West Nile virus, because of the small molecules broad immune-enhancing activity. Target: Influenza Virus. Smiles: O=C(Nc1nc2ccc3scnc3c2s1)c1ccc2ccccc2c1. References: Probst P., et al. A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response.