Kartogenin

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-binding protein, filamin A, which disrupts its interaction with the transcription factor core-binding factor beta subunit (CBFbeta). When dissociated from filamin A, CBFbeta translocates to the nucleus and forms a transcriptional complex with the runt-related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-induced damage in osteoarthritic bovine articular chondrocytes in vitro.Formal Name: 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-benzoic acid. CAS Number: 4727-31-5. Molecular Formula: C20H15NO3. Formula Weight: 317.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 281 nm. SMILES: OC(C1=CC=CC=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=O)=O. InChi Code: InChI=1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24). InChi Key: SLUINPGXGFUMLL-UHFFFAOYSA-N.