Kaempferol

Kaempferol is a flavonoid which is abundant in a variety of plant leaves and fruits. It has diverse physiological activities through both direct and indirect effects. For example, kaempferol directly binds estrogen receptors alpha and beta, acting as an inverse agonist or agonist. It also acts as an antioxidant, which presumably contributes to its ability to suppress advanced glycation endproduct-induced NADPH oxidase, NF-kappaB signaling, and hypoxia-inducible factor-related angiogenesis and VEGF expression. Kaempferol also suppresses signaling through certain receptor tyrosine kinases, including EGFR and HGF.Formal Name: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 520-18-3. Synonyms: Nimbecetin, NSC 407289, NSC 656277, Pelargidenon, Rhamnolutein, Swartziol, Trifolitin. Molecular Formula: C15H10O6. Formula Weight: 286.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml. lambdamax: 204, 267, 368 nm. SMILES: OC1=C(C2=CC=C(O)C=C2)OC3=C(C1=O)C(O)=CC(O)=C3. InChi Code: InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H. InChi Key: IYRMWMYZSQPJKC-UHFFFAOYSA-N. Origin: Plant/Centella asiatica.