Kaempferitrin

Kaempferitrin is a flavonoid glycoside that has been found in B. pinnatum and has diverse biological activities. It scavenges DPPH radicals (IC50 = 8.73 µg/ml) and is active against the bacteria S. aureus, P. aeruginosa, and S. typhi, as well as the fungi C. albicans, C. parapsilosis, and C. neoformans (MICs = 16-32 µg/ml). Kaempferitrin inhibits LPS-and IFN-gamma-induced nitric oxide (NO) production in isolated mouse macrophages (IC50 = 40 µM). It decreases blood glucose levels in a rat model of alloxan-induced diabetes when administered at a dose of 100 mg/kg.Formal Name: 3,7-bis[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 482-38-2. Synonyms: BRN 0073958, Grosvenorine II, Kaempferol 3,7-O-alpha-Dirhamnoside, Lespedin. Molecular Formula: C27H30O14. Formula Weight: 578.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Ethanol: soluble. SMILES: OC1=C(C(C(O[C@@H]2O[C@@H](C)[C@H](O)[C@@H](O)[C@H]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=CC(O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)=C1. InChi Code: InChI=1S/C27H30O14/c1-9-17(30)20(33)22(35)26(37-9)39-13-7-14(29)16-15(8-13)40-24(11-3-5-12(28)6-4-11)25(19(16)32)41-27-23(36)21(34)18(31)10(2)38-27/h3-10,17-18,20-23,26-31,33-36H,1-2H3/t9-,10-,17-,18-,20+,21+,22+,23+,26-,27-/m0/s1. InChi Key: PUPKKEQDLNREIM-QNSQPKOQSA-N. Origin: Plant/Calendula officinalis.