K145 hydrochloride

Description: K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity. Target: S1P Receptor, Apoptosis. Smiles: Cl.CCCCOc1ccc(CC\C=C2/SC(=O)N(CCN)C2=O)cc1. References: Liu K, et al. Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent. PLoS One. 2013,8(2):e56471.