JW 642

JW 642 is an inhibitor of monoacylglycerol lipase (MAGL, IC50s = 3.7, 7.6, and 14 nM for the human, mouse, and rat enzymes, respectively). It is selective for MAGL over fatty acid amide hydrolase (FAAH, IC50s = 20.6, 31, and 14 µM for the human, mouse, and rat enzymes, respectively), as well as alpha/beta-hydrolase domain-containing protein 6 (ABHD6, IC50s = 107 and 50 nM for the mouse and rat enzymes, respectively).Formal Name: 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate. CAS Number: 1416133-89-5. Molecular Formula: C21H20F6N2O3. Formula Weight: 462.4. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 11 mg/ml, DMSO: 5 mg/ml, Ethanol: 13 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. SMILES: O=C(OC(C(F)(F)F)C(F)(F)F)N1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1. InChi Code: InChI=1S/C21H20F6N2O3/c22-20(23,24)18(21(25,26)27)32-19(30)29-11-9-28(10-12-29)14-15-5-4-8-17(13-15)31-16-6-2-1-3-7-16/h1-8,13,18H,9-12,14H2. InChi Key: AVSCNEOUWSVZEY-UHFFFAOYSA-N. License: Sold under license from The Scripps Research Institute..