JNJ16259685

Description: JNJ16259685 (TN.T 16259685) is a selective mGluR1 antagonist, and inhibits the synaptic activation of mGluR1 in a concentration-dependent manner with IC50 of 19 nM. Target: GluR. Smiles: CO[C@H]1CC[C@H](CC1)C(=O)c1ccc2nc3OCCCc3cc2c1. References: Hodgson RA, et al. Characterization of the selective mGluR1 antagonist, JNJ16259685, in rodent models of movement and coordination. Pharmacol Biochem Behav. 2011 Apr,98(2):181-7.