JH-II-127

Description: JH-II-127 is an oral inhibitor of leucine-rich repeat kinase 2 (LRRK2), targeting WT LRRK2, G2019S LRRK2, and A2016T LRRK2 with IC50 values of 6.6 nM, 2.2 nM, and 47.7 nM, respectively. Target: LRRK2. Smiles: CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)nc2[nH]cc(Cl)c12. References: Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor[J]. ACS Medicinal Chemistry Letters, 2015, 6(5):584-589.