JC2-11

Description: JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical (NC) inflammatory vesicles by disrupting reactive oxygen species (ROS) production and caspase-1 activity.JC2-11 reduces caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1beta and lactate dehydrogenase (LDH) activity in inflammatory vesicles. JC2-11 reduced caspase-1 (p20) secretion, gasdermin D (GSDMD) cleavage, IL-1beta and lactate dehydrogenase (LDH) release from inflammatory vesicles. Target: IL Receptor, AIM2, ROS, Dehydrogenase, NOD-like Receptor (NLR), Caspase. Smiles: C(/C=C/C1=CC(OC)=C(O)C=C1)(=O)C2=CC(F)=C(OC)C=C2. References: Lee G, et al. JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022,12(1):22484.