Jasplakinolide

Description: Jasplakinolide(Jaspamide), a naturally occurring cyclic peptide from marine sponges, is a potent inducer of actin polymerization.Jasplakinolide exhibits antifungal and antitumor activity and stabilizes pre-existing actin filaments. Jasplakinolide competitively binds to F-actin with the ghost pen cyclic peptide and has a Kd value of 15 nM for F-actin. Target: Antifungal, Microtubule Associated. Smiles: C(C=1C=2C(NC1Br)=CC=CC2)[C@@H]3C(=O)N[C@H](CC(=O)O[C@@H](C)C[C@@H](C)\C=C(\C)/C[C@H](C)C(=O)N[C@@H](C)C(=O)N3C)C4=CC=C(O)C=C4. References: Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27,269(21):14869-71.