JAK3-IN-2

JAK3-IN-2 is an inhibitor of JAK3 (Ki = 0.07 nM). It is selective for JAK3 over JAK1 and JAK2 (Kis = 320 and 740 nM, respectively). JAK3-IN-2 inhibits IL-2-induced STAT5 gene expression in a reporter assay (IC50 = 70 nM). In vivo, JAK3-IN-2 (100, 300, and 600 mg/kg) reduces paw swelling and ankle bone loss in a rat model of collagen-induced arthritis.Formal Name: 4-[3-[(2-methyl-1-oxo-2-propen-1-yl)amino]phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, ethyl ester. CAS Number: 1443235-95-7. Synonyms: JAK3-Inhibitor 2, Janus-Associated Kinase 3 Inhibitor 2. Molecular Formula: C19H18N4O3. Formula Weight: 350.4. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. lambdamax: 250 nm. SMILES: O=C(C1=CNC2=NC=NC(C3=CC(NC(C(C)=C)=O)=CC=C3)=C21)OCC. InChi Code: InChI=1S/C19H18N4O3/c1-4-26-19(25)14-9-20-17-15(14)16(21-10-22-17)12-6-5-7-13(8-12)23-18(24)11(2)3/h5-10H,2,4H2,1,3H3,(H,23,24)(H,20,21,22). InChi Key: NJPHKVOXHRAPGJ-UHFFFAOYSA-N.