J27644

J27644 is an inhibitor of histone deacetylase 6 (HDAC6, IC50 = 10 nM). It is selective for HDAC6 over HDAC1-5 (IC50s = 211-516 nM) and HDAC7, -8, -9, and -11 (IC50s = 137-812 nM). J27644 (10 µM) reduces the level of proteins involved in fibrosis, including collagen 1A1, alpha-smooth muscle actin (alpha-SMA), and fibronectin, in human pulmonary fibroblasts in vitro.Formal Name: 4-((8-chloro-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)methyl)-N-hydroxybenzamide. Molecular Formula: C16H12ClN3O4. Formula Weight: 345.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Methanol: Soluble. SMILES: O=C(C1=CC=CC(Cl)=C1N2CC3=CC=C(C(NO)=O)C=C3)NC2=O. InChi Code: InChI=1S/C16H12ClN3O4/c17-12-3-1-2-11-13(12)20(16(23)18-15(11)22)8-9-4-6-10(7-5-9)14(21)19-24/h1-7,24H,8H2,(H,19,21)(H,18,22,23). InChi Key: OWMZGLVMABQUAQ-UHFFFAOYSA-N.