IXA4

IXA4 is an activator of inositol-requiring enzyme 1 (IRE1). It induces the expression of the Ire1 target Xpb1s in primary mouse hepatocytes. In vivo, IXA4 (50 mg/kg) decreases hepatic expression of the Xbp1 target gene Dnajb9 in wild-type mice and a mouse model of high-fat diet-induced obesity, effects that can be reversed by the IRE1 inhibitor STF-083010 (Cay-17370). IXA4 also increases glucose tolerance and suppresses hepatic gluconeogenesis and steatosis in a mouse model of high-fat diet-induced obesity.Formal Name: N-methyl-N-[2-(4-methylphenoxy)ethyl]-4-[(1-oxo-3-phenoxypropyl)amino]-1H-pyrazole-1-acetamide. CAS Number: 1185329-96-7. Molecular Formula: C24H28N4O4. Formula Weight: 436.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/mL, DMSO: 10 mg/mL, PBS (pH 7.2): 0.3 mg/mL. SMILES: O=C(N(C)CCOC1=CC=C(C)C=C1)CN2N=CC(NC(CCOC3=CC=CC=C3)=O)=C2. InChi Code: InChI=1S/C24H28N4O4/c1-19-8-10-22(11-9-19)32-15-13-27(2)24(30)18-28-17-20(16-25-28)26-23(29)12-14-31-21-6-4-3-5-7-21/h3-11,16-17H,12-15,18H2,1-2H3,(H,26,29). InChi Key: ZVSKMVAWWBSNOY-UHFFFAOYSA-N.