Itacitinib

Itacitinib is an inhibitor of JAK1. It is greater than 20- and 200-fold selective for JAK1 over JAK2 and JAK3, respectively.Formal Name: 1-[1-[[3-fluoro-2-(trifluoromethyl)-4-pyridinyl]carbonyl]-4-piperidinyl]-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile. CAS Number: 1334298-90-6. Synonyms: INCB 039110. Molecular Formula: C26H23F4N9O. Formula Weight: 553.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3mg/mL, DMF:PBS (pH 7.2) (1:40): 0.02mg/mL, DMSO: 2.5mg/mL, Ethanol: 5mg/mL, Ethanol:PBS (pH 7.2) (1:40): 0.02mg/mL. lambdamax: 255, 311 nm. SMILES: O=C(C1=C(F)C(C(F)(F)F)=NC=C1)N2CCC(N3CC(CC#N)(N4C=C(C5=NC=NC6=C5C=CN6)C=N4)C3)CC2. InChi Code: InChI=1S/C26H23F4N9O/c27-20-18(1-7-32-22(20)26(28,29)30)24(40)37-9-3-17(4-10-37)38-13-25(14-38,5-6-31)39-12-16(11-36-39)21-19-2-8-33-23(19)35-15-34-21/h1-2,7-8,11-12,15,17H,3-5,9-10,13-14H2,(H,33,34,35). InChi Key: KTBSXLIQKWEBRB-UHFFFAOYSA-N.