Isoimperatorin

Isoimperatorin is a natural furanocoumarin that can be isolated from a variety of plant parts. It inhibits cytochrome P450 (CYP) isoform 1A activity, in particular blocking hepatic ethoxyresorufin O-dealkylase activity. Through its effects on CYP1A, isoimperatorin reduces the metabolism of polycyclic aromatic hydrocarbons and aflatoxin B1 (Cay-11293) to reactive metabolites. Isoimperatorin also induces the expression of glutathione S-transferase alpha by activating Nrf2.Formal Name: 4-[(3-methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one. CAS Number: 482-45-1. Molecular Formula: C16H14O4. Formula Weight: 270.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 221, 250, 259, 268, 309 nm. SMILES: O=C1OC2=C(C(OC/C=C(C)/C)=C(C=CO3)C3=C2)C=C1. InChi Code: InChI=1S/C16H14O4/c1-10(2)5-7-19-16-11-3-4-15(17)20-14(11)9-13-12(16)6-8-18-13/h3-6,8-9H,7H2,1-2H3. InChi Key: IGWDEVSBEKYORK-UHFFFAOYSA-N.